Neurobiology of Disease NKG2D-Mediated Cytotoxicity toward Oligodendrocytes Suggests a Mechanism for Tissue Injury in Multiple Sclerosis
نویسندگان
چکیده
Philippe Saikali,1 Jack P. Antel,1 Jia Newcombe,3 Zhihong Chen,4 Mark Freedman,4 Manon Blain,1 Romain Cayrol,5 Alexandre Prat,5 Jeffery A. Hall,2 and Nathalie Arbour1,5 1Neuroimmunology Unit, Montreal Neurological Institute, and 2Division of Neurosurgery, McGill University, Montreal, Quebec, Canada H3A 2B4, 3NeuroResource, University College London, Institute of Neurology, London WC1N 1PJ, United Kingdom, 4Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada K1H 8L6, and 5Research Center-Centre Hospitalier de l’Université de Montréal, University of Montreal, Montreal, Quebec, Canada H2L 4M1
منابع مشابه
Cytotoxic NKG2C+ CD4 T cells target oligodendrocytes in multiple sclerosis.
The mechanisms whereby immune cells infiltrating the CNS in multiple sclerosis patients contribute to tissue injury remain to be defined. CD4 T cells are key players of this inflammatory response. Myelin-specific CD4 T cells expressing CD56, a surrogate marker of NK cells, were shown to be cytotoxic to human oligodendrocytes. Our aim was to identify NK-associated molecules expressed by human CD...
متن کاملReview of NKG2D function and its related ligands: review article
The natural killer group 2D (NKG2D) is a transmembrane protein and a member of the CD94/NKG2 family of C-type lectin-like receptors. NKG2D is encoded by the KLRK1 gene, which is located in the NK-gene complex (NKC) placed on chromosomes 6 and 12 in mice and humans, respectively. NKG2D forms a homodimer structure and binds through ectodomains with its related ligands. Each of its monomers consis...
متن کاملNon-MHC-restricted cell-mediated lysis of human oligodendrocytes in vitro: relation with CD56 expression.
Oligodendrocytes and their myelin membranes are the apparent target of the autoimmune response that characterizes the human adult central nervous system-demyelinating disease multiple sclerosis. Human oligodendrocytes do not express MHC class II molecules, a requirement for MHC-restricted injury mediated by myelin-reactive CD4+ T cells, the cell type implicated in initiating the disease process...
متن کاملP 153: Neuroinflammation in Multiple Sclerosis
Multiple sclerosis (MS) is a complex disease which is correlated with increasing inflammatory factors, demyelination and axonal loss. In this auto-immune disease, Neuroinflammation is mediated by different types of T cells with macrophage/microglial activation and B cells involvement that interact in a collaborative manner. Focal inflammation is the main cause for the onset of relapses and coul...
متن کاملP 53: Stem Cell Therapy for Treatment of Autoimmune Diseases (with Emphasis on Multiple Sclerosis)
Autoimmune diseases have been described as an interesting and poorly understood group of disorders. There are many challenges in the respective scientific societies concerning the nature, causes and the therapeutic approaches of these diseases. In accordance with the evidences the nature and etiology of these disorders is multifactorial and complex but the clearest definition could be expressed...
متن کامل